Key result
Acute quadriplegic myopathy following corticosteroid and neuromuscular blocker exposure is associated with a specific decrease in thick-filament proteins and impaired force-generating capacity.
Population
Critically ill patients with sepsis in the ICU who developed acute quadriplegic myopathy after receiving…
Design
Case_series
Follow-up
Acute phase and during recovery
Authors
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Biopsy evidence of myosin loss in AQM supports drug-related myopathy; leaves open causality and need for prospective confirmation.
Observational
Yes
Acute quadriplegic myopathy following corticosteroid and neuromuscular blocker use in ICU patients is associated with a reversible loss of thick-filament proteins and altered transcription, though acute paralysis may stem from impaired membrane excitability.
Larsson et al. (2000) conducted an observational in Acute quadriplegic myopathy. Corticosteroids and nondepolarizing neuromuscular blocking agents was evaluated on Mechanisms underlying acute quadriplegic myopathy (myofibrillar protein content, myosin loss, muscle cell force-generating capacity). Acute quadriplegic myopathy following corticosteroid and neuromuscular blocker exposure is associated with a specific decrease in thick-filament proteins and impaired force-generating capacity.
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