The study demonstrates how specific progenitors regulate germ cell formation, indicating a breakthrough for gametogenesis research.
progenitors upstream of PRDM1 to regulate the expression of SOX17. This serves to protect hPGCLCs from crossing the Weismann's barrier to adopt somatic cell fates and, therefore, is an essential mechanism for successfully initiating in vitro gametogenesis.
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Chen et al. (2019) studied this question.
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