Gender-Specific Alterations in Fibrin Structure Function in Type 2 Diabetes: Associations with Cardiometabolic and Vascular Markers
Key result
Women with type 2 diabetes had more compact clots with higher maximum absorbance (0.37 vs 0.34 AU, P<0.001) and longer lysis times (803 vs 665 sec, P<0.001) compared with men.
Why the study?
Are there gender-specific differences in fibrin clot structure and fibrinolysis in patients with type 2 diabetes?
Population
875 participants with type 2 diabetes from the Edinburgh Type 2 Diabetes Study, age 68 years, 450 males.
Design
Cohort
Authors
Discussion
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Member takes
Implication
May underlie sex differences in CV risk in T2D; hypothesis-generating for targeted antithrombotic strategies.
Study Design
Type
Cohort (n=875)
Structured PICO
Are there gender-specific differences in fibrin clot structure and fibrinolysis in patients with type 2 diabetes?
P
Population
875 adults aged 60-75 years with type 2 diabetes from the Edinburgh Type 2 Diabetes Study.
O
Outcome
Fibrin clot structure and fibrinolysis parameters (including clot maximum absorbance and lysis time) and their associations with cardiometabolic risk factors and vascular pathologysurrogate
Main Result
Absolute Event Rate: 0.37% vs 0.34%
p-value: p=<0.001
Women with type 2 diabetes exhibit a more prothrombotic fibrin clot structure with compromised fibrinolysis compared to men, which may contribute to gender differences in cardiovascular risk.
Cite This Study
Alzahrani et al. (2012) conducted a cohort in Type 2 diabetes (n=875). Female gender vs. Male gender was evaluated on Clot maximum absorbance (arbitrary units) (p=<0.001). Women with type 2 diabetes had more compact clots with higher maximum absorbance (0.37 vs 0.34 AU, P<0.001) and longer lysis times (803 vs 665 sec, P<0.001) compared with men.