What is the clinical evidence from this study?

Study design: Observational. Population: Enterovirus A71 (EV-A71) (n=155). Intervention: Genomic recombination analysis. Primary outcome: Recombination breakpoints and signatures.

June 21, 2018Emerging Microbes & InfectionsOpen Access

Discovery of Enterovirus A71-like nonstructural genomes in recent circulating viruses of the Enterovirus A species

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Key result

Genomic analysis of 155 EV-A71 genomes revealed extensive recombination and identified 11 EV-A71-like signatures in cocirculating EV-A viruses, suggesting targets for wide-spectrum antivirals.

Authors

KLKuo-Ming LeeChang Gung University YGYu‐Nong GongJohns Hopkins University THTzu-Hsuan HsiehLinkou Chang Gung Memorial Hospital

Discussion

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Implication

EV-A71-like signatures in cocirculating EV-A viruses may guide broad antivirals; extends recombination mapping but leaves open clinical validation.

Study Design

Type

Observational (n=155)

PICO

Population

155 full-length EV-A71 genomes from clinical isolates (2005-2016) and databases in Taiwan analyzed to evaluate viral recombination.

Exposure / Comparator

Genomic recombination analysis

Primary Outcome

Recombination breakpoints and signatures

Cite This Study

Lee et al. (2018) conducted an observational in Enterovirus A71 (EV-A71) (n=155). Genomic recombination analysis was evaluated on Recombination breakpoints and signatures. Genomic analysis of 155 EV-A71 genomes revealed extensive recombination and identified 11 EV-A71-like signatures in cocirculating EV-A viruses, suggesting targets for wide-spectrum antivirals.

synapsesocial.com/papers/6a69e779ba61fbfa0247fb5a https://doi.org/10.1038/s41426-018-0107-0

View Full Paper

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Implication

EV-A71-like signatures in cocirculating EV-A viruses may guide broad antivirals; extends recombination mapping but leaves open clinical validation.

Discovery of Enterovirus A71-like nonstructural genomes in recent circulating viruses of the Enterovirus A species

Discussion

Member takes

Implication

Study Design

PICO

Cite This Study

Discovery of Enterovirus A71-like nonstructural genomes in recent circulating viruses of the Enterovirus A species

Discussion

Member takes

Implication

Study Design

PICO

Cite This Study

Also Consider

Also Consider