Key result
EV68 3C protease cleaves the TRIF adaptor protein, abolishing its capacity to activate NF-κB and IFN-β signaling and subverting host innate immune responses.
Population
HeLa cells infected with human enterovirus 68 (EV68)
Design
Preclinical
Authors
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EV68 inhibits TLR3 innate responses; leaves open its role in disease severity and antiviral targets.
EV68 subverts host innate immune responses by using its 3C protease to cleave TRIF, impairing type I interferon production.
Xiang et al. (2014) studied Human enterovirus 68 (EV68) infection. EV68 3C protease was evaluated on TRIF cleavage and activation of NF-κB and IFN-β signaling. EV68 3C protease cleaves the TRIF adaptor protein, abolishing its capacity to activate NF-κB and IFN-β signaling and subverting host innate immune responses.