Four-component, quadruple cascade, one catalyst: An asymmetric four-component (ABC2) quadruple cascade reaction initiated by oxa-Michael addition of aliphatic alcohols to acrolein is reported (see scheme) to provide high yields of trisubstituted highly functionalized cyclohexene carbaldehydes with excellent diastereomeric and complete enantiomeric control. This process can be explained by an iminium (Im)–enamine (En)–iminium (Im)–enamine (En) sequence mechanism.
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Zhang et al. (2009) studied this question.
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