Key result
A variational optimal control approach with a penalty strategy successfully reconstructed cardiac output blood flow from distal pressure measurements, demonstrating robustness to noise.
Why the study?
The study aimed to derive a reliable, stable, and accurate inverse problem strategy to reconstruct cardiac output blood flow entering the ascending aorta from distal pressure measurements.
Population
Real pressure recordings during anesthesia and a reduced one-dimensional model of the aorta
Design
Computational modeling and variational optimal control simulation study
Authors
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May enable distal-pressure-based cardiac output monitoring; leaves open prospective human validation before any clinical use.
A novel mathematical approach using optimal control can robustly reconstruct central cardiac output from distal arterial pressure measurements.
Imperiale et al. (2023) studied Hemodynamics. Variational optimal control approach was evaluated on Reconstruction of inlet flow from distal pressure measurement. A variational optimal control approach with a penalty strategy successfully reconstructed cardiac output blood flow from distal pressure measurements, demonstrating robustness to noise.
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