Key result
Augmenting flow model calibration with slip/transpiration boundary conditions considerably improved the accuracy of estimated pressure gradients and 3D velocity fields when vessel geometry is uncertain.
Why the study?
Computational geometry in blood flow simulations is limited by anatomical image resolution, and applying standard no-slip boundary conditions to inaccurate boundaries can cause large errors in pressure gradients.
Using slip/transpiration boundary conditions calibrated with velocity measurements improves the accuracy of computational blood flow simulations when anatomical image resolution is limited.
May refine hemodynamic modeling under imaging uncertainty; hypothesis-generating and requires prospective clinical validation.
Numerical blood flow simulations are typically set up from anatomical medical images and calibrated using velocity measurements. However, the accuracy of the computational geometry itself is limited by the resolution of the anatomical image. We first show that applying standard no-slip boundary conditions on inaccurately extracted boundaries can cause large errors in the results, in particular the pressure gradient. In this work, we therefore propose to augment the flow model calibration by slip/transpiration boundary conditions, whose parameters are then estimated using velocity measurements. Numerical experiments show that this methodology can considerably improve the accuracy of the estimated pressure gradients and 3D velocity fields when the vessel geometry is uncertain.
No takes yet. Share an insight, caveat, or question.
Nolte et al. (2019) studied this question. Slip/transpiration boundary conditions vs. Standard no-slip boundary conditions was evaluated on Accuracy of estimated pressure gradients and 3D velocity fields. Augmenting flow model calibration with slip/transpiration boundary conditions considerably improved the accuracy of estimated pressure gradients and 3D velocity fields when vessel geometry is uncertain.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: