Key result
HSV entry can be mediated by two structurally unrelated gD receptors (HveC and HveA) through related but not identical binding interactions with glycoprotein D.
Population
In vitro models studying Herpes Simplex Virus glycoprotein D and its receptors
Design
Preclinical
Authors
Loading...
May guide antiviral development in preclinical models; leaves open clinical relevance of dual receptor blockade.
HSV entry can be mediated by two structurally unrelated receptors (HveC and HveA) that bind to glycoprotein D in related but distinct ways.
Krummenacher et al. (1998) studied Herpes simplex virus (HSV) entry. HveC and HveA binding to HSV glycoprotein D was evaluated on Binding interactions between HSV glycoprotein D and HveC/HveA. HSV entry can be mediated by two structurally unrelated gD receptors (HveC and HveA) through related but not identical binding interactions with glycoprotein D.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: