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Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, characterized by high aggressiveness and metastatic potential. Sequential treatment with neoadjuvant chemotherapy, surgery, and targeted therapy forms the standard care. Radiotherapy is reserved for unresectable tumours or margin-positive resections, given its limited efficacy in OS. Programmed cell death (PCD) plays a crucial role in bodily growth and development and is regulated by numerous genes. It is noteworthy that in addition to apoptosis, ferroptosis and pyroptosis are also involved in the development of OS. This review provides an overview of the regulatory mechanisms of apoptosis, ferroptosis and pyroptosis in OS, with a focus on developing new therapeutic strategies of this disease.
Ding et al. (Mon,) studied this question.