Key result
Paired stimulation of the EN5 and peripheral chemoreceptors caused a progressive and significant potentiation of EN5-evoked diving bradycardia, involving 5-HT3 receptors in the NTS.
Population
In situ working heart-brain stem preparation
Comparison
Repetitive paired stimulation of the trigeminal… vs EN5 stimulation alone
Design
Preclinical
Authors
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Animal data implicate NTS 5-HT3 receptors in chemoreflex-potentiated bradycardia; leaves open human translation.
The potentiation of submaximal diving bradycardia requires peripheral chemoreceptor drive and involves neurotransmission via 5-HT3 receptors within the nucleus tractus solitarii.
Rozložník et al. (2008) studied Diving bradycardia. Paired stimulation of the trigeminal ethmoidal nerve (EN5) and peripheral chemoreceptors vs. EN5 stimulation alone was evaluated on EN5-evoked diving bradycardia. Paired stimulation of the EN5 and peripheral chemoreceptors caused a progressive and significant potentiation of EN5-evoked diving bradycardia, involving 5-HT3 receptors in the NTS.
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