Key result
Newly formed human platelets are more active in protein synthesis, larger, less dense, and have lower thrombosthenin content compared to mature platelets.
Newly formed human platelets differ from mature platelets by having a higher capacity for protein synthesis, larger size, lower density, and lower thrombosthenin content.
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Platelet heterogeneity may affect function; animal data leave open relevance to human thrombosis or antiplatelet therapy.
Summary Human platelets have been separated into 4 more homogeneous populations (A, B, C, and D; D population of highest density) by isopycnic density gradient centrifugation. Newly formed platelets have been identified in band C. These newly formed platelets age in vivo and shift into band D containing mature and old platelets. Newly formed platelets are more active in their ability to incorporate labeled amino acids into protein than mature and/or older platelets. The maturation of newly formed platelets (shift from band C to band D) is concurrent with a gradual loss in their ability to synthesize protein, a increase in density and decrease in size. In addition, newly formed platelets have a lower content of thrombosthenin than do mature (old) platelets.
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Booyse et al. (1971) studied this question. Platelet age (newly formed vs mature) vs. Mature and old platelets was evaluated on Protein synthesis, density, size, and thrombosthenin content. Newly formed human platelets are more active in protein synthesis, larger, less dense, and have lower thrombosthenin content compared to mature platelets.
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