January 1, 1977Blood

Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure

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Population

15 normal subjects providing human whole blood platelets

Design

Preclinical

Authors

LCL Corash HTH Tan HGHR GralnickRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Density fractionation reveals platelet heterogeneity; leaves open its role in modeling senescence for human thrombosis research.

Structured PICO

Population

15 normal subjects providing human whole blood platelets

Intervention

Isosmotic arabino-galactan (Stractan) solutions and isopycnic centrifugation for platelet isolation and fractionation

Outcome

Correlation of platelet density with volume and ultrastructuresurrogate

A novel high-yield method for fractionating human platelets demonstrates significant differences in volume and granule content between light and heavy platelets, suggesting aging as a determinant of platelet heterogeneity.

Cite This Study

Corash et al. (1977) studied this question.

synapsesocial.com/papers/6a880df0aaaef52b1e4ded4c https://doi.org/10.1182/blood.v49.1.71.bloodjournal49171

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Bookmark

Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Heterogeneity of human whole blood platelet subpopulations. I. Relationship between buoyant density, cell volume, and ultrastructure

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider