Key result
Sympathetic activation and deactivation modulated the cerebrovascular response to CO2, with regression slopes of 1.3 during tilt and 2.3 during blockade vs 1.6 cm/(s·mm Hg) supine (P<0.05).
Why the study?
How does sympathetic nervous system activity interact with carbon dioxide to regulate cerebral perfusion in healthy humans?
Population
6 healthy subjects, aged 29+/-4 years
Comparison
Sympathetic activation and sympathetic… vs Supine position (baseline sympathetic tone)
Design
Other
Authors
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Hypothesis-generating in healthy subjects; leaves open sympathetic effects on cerebral autoregulation in hypertension.
How does sympathetic nervous system activity interact with carbon dioxide to regulate cerebral perfusion in healthy humans?
p-value: p=<0.05
The sympathetic nervous system attenuates CO2-induced increases in cerebral blood flow, indicating a moderate direct effect on the cerebral vasculature.
Jordan et al. (2000) studied Healthy subjects (n=6). Sympathetic activation (head-up tilt) and deactivation (ganglionic blockade) vs. Supine position was evaluated on Slope of the regression between PaCO2 and mean cerebral blood flow velocity (p=<0.05). Sympathetic activation and deactivation modulated the cerebrovascular response to CO2, with regression slopes of 1.3 during tilt and 2.3 during blockade vs 1.6 cm/(s·mm Hg) supine (P<0.05).
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