Key result
Phenylpropanolamine hydrochloride (25 mg) significantly increased systolic (32 mm Hg), diastolic (15 mm Hg), and mean (21 mm Hg) blood pressures in patients with autonomic failure.
Why the study?
Does oral phenylpropanolamine hydrochloride increase blood pressure in patients with autonomic failure and orthostatic hypotension?
Does oral phenylpropanolamine hydrochloride increase blood pressure in patients with autonomic failure and orthostatic hypotension?
Mean Difference: 32
Oral phenylpropanolamine elicits a potent pressor response in patients with orthostatic hypotension, which may lead to significant hypertension.
May increase sitting BP in autonomic failure; leaves open therapeutic role in orthostatic hypotension.
We determined the pressor effect of phenylpropanolamine hydrochloride, a widely used sympathomimetic agent, in 14 patients with autonomic failure and orthostatic hypotension. Blood pressure was monitored every five minutes in the sitting position with an automated device. Oral administration of 25 mg of phenylpropanolamine hydrochloride in nine patients produced significant increases in systolic (32 mm Hg), diastolic (15 mm Hg), and mean (21 mm Hg) blood pressures. The pressor effect appeared within the first 60 minutes and was still present at 105 minutes. There was no change in heart rate. Blood pressure was also significantly raised by administration of 12.5 mg of oral phenylpropanolamine hydrochloride in five additional patients. We conclude that administration of 25 mg of phenylpropanolamine hydrochloride elicits a potent pressor response in patients with orthostatic hypotension and that significant hypertension may result.
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Italo Biaggioni (1987) studied Autonomic failure and orthostatic hypotension (n=14). Phenylpropanolamine hydrochloride was evaluated on Blood pressure (systolic, diastolic, mean) (32 mm Hg increase in systolic BP). Phenylpropanolamine hydrochloride (25 mg) significantly increased systolic (32 mm Hg), diastolic (15 mm Hg), and mean (21 mm Hg) blood pressures in patients with autonomic failure.
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