Key result
Phenylpropanolamine shows no effect on 24-hour mean blood pressure versus placebo in normotensive men.
Why the study?
The pressor effects of therapeutic doses of phenylpropanolamine are not well established.
Does phenylpropanolamine increase ambulatory blood pressure in normotensive male subjects?
Comparison
75 mg phenylpropanolamine vs placebo
Design
Double-blind crossover randomized trial
Follow-up
6 days per period
Authors
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Supports safe use of sustained-release PPA without BP concerns in normotensive men; confirms absence of pressor effect in this RCT.
RCT (n=18)
Double-blind
Randomly assigned
Does phenylpropanolamine increase ambulatory blood pressure in normotensive male subjects?
Therapeutic doses of sustained-release phenylpropanolamine do not cause a significant pressor effect in normotensive men.
Goodman et al. (1986) conducted an RCT in Normotensive (n=18). Phenylpropanolamine (PPA) vs. Placebo was evaluated on 24-hour global mean blood pressure. Phenylpropanolamine 75 mg did not significantly affect 24-hour global mean blood pressure compared to placebo in normotensive men (119/69 vs 117/68 mmHg on day 6).
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