Key result
Oral phenylpropanolamine causes a rapid and dangerous BP spike during MAOI therapy, reversible by phentolamine.
Why the study?
Severe hypertensive episodes due to interactions between phenylpropanolamine and monoamine oxidase inhibitors were not well characterized.
Does phenylpropanolamine cause dangerous blood pressure elevations in patients taking monoamine oxidase inhibitors?
Population
Three healthy volunteers and one subject on monoamine oxidase inhibitor tranylcypromine
Comparison
Phenylpropanolamine 50 mg and 100 mg oral doses in free and slow-release forms and proprietary cough linctus
Design
Experimental study in healthy volunteers and a patient
Authors
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Warrants caution prescribing phenylpropanolamine to MAOI users; single case leaves interaction incidence and generalizability open.
Does phenylpropanolamine cause dangerous blood pressure elevations in patients taking monoamine oxidase inhibitors?
Phenylpropanolamine, commonly found in cough and cold remedies, can cause severe hypertensive crises in patients taking monoamine oxidase inhibitors.
Cuthbert et al. (1969) studied Healthy volunteers and patients on monoamine oxidase inhibitors (n=4). Phenylpropanolamine vs. Slow-release preparations was evaluated on Blood pressure changes. Oral phenylpropanolamine caused a rapid and potentially dangerous rise in blood pressure in a subject taking a monoamine oxidase inhibitor, which was reversed by phentolamine.
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