September 1, 1977Clinical Pharmacology & Therapeutics
Phentolamine testing for alpha adrenergic participation in hypertensive patients: Independence from renin profiles
Why the study?
Does phentolamine infusion reduce blood pressure in hypertensive patients independently of renin profiles?
Population
30 seated hypertensive patients
Design
Cohort
Follow-up
20 minutes
Authors
Discussion
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Member takes
Implication
Phentolamine-associated BP reduction supports alpha-adrenergic contribution to hypertension beyond renin-sodium indices; hypothesis-generating and should not yet change practice.
Structured PICO
Does phentolamine infusion reduce blood pressure in hypertensive patients independently of renin profiles?
P
Population
30 seated hypertensive patients
I
Intervention
Phentolamine 1 mg/min infused for 20 min
O
Outcome
Change in diastolic and systolic blood pressuresurrogate
Alpha adrenergic factors participate in sustaining blood pressure in hypertensive patients independently of the renin-angiotensin system and sodium balance.
Cite This Study
Drayer et al. (1977) studied this question.