Population
Pial arteries of cats
Comparison
Phentolamine applied via microapplication… vs Norepinephrine alone or baseline resting tone
Design
Preclinical
Authors
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Phentolamine competitively blocks norepinephrine constriction without altering resting tone in feline pial arteries; leaves open translation to human cerebrovascular regulation.
Phentolamine competitively antagonizes norepinephrine-induced constriction in cat pial arteries, but resting tone is not influenced by an alpha-adrenergic component.
Kuschinsky et al. (1975) studied this question.
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