Why the study?
Does a higher dose of phentolamine (1 mg/kg) better block alpha-adrenoceptor function compared to a lower dose (0.5 mg/kg) in patients with chronic extremity pain?
Does a higher dose of phentolamine (1 mg/kg) better block alpha-adrenoceptor function compared to a lower dose (0.5 mg/kg) in patients with chronic extremity pain?
A phentolamine dose of 1 mg/kg over 10 min provides more complete alpha-adrenoceptor blockade than 0.5 mg/kg over 20 min for diagnosing sympathetically maintained pain.
No takes yet. Share an insight, caveat, or question.
May support 1 mg/kg phentolamine for SMP diagnosis; hypothesis-generating and should not yet change practice.
Raja et al. (1996) studied this question.
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