Population
Canine blood-perfused skeletal muscle in situ (desipramine-pretreated)
Design
Preclinical
Authors
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No change to alpha-blocker use; extends animal evidence for prejunctional α2 feedback but leaves clinical translation open.
The study supports the concept of a quantitatively important prejunctional alpha 2-adrenoceptor-mediated feedback inhibition of NE release in vivo in the skeletal muscle vasculature.
Kahan et al. (1987) studied this question.
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