Why the study?
Does beta-adrenoceptor blockade reduce nerve stimulation evoked release of endogenous noradrenaline in canine skeletal muscle?
Population
Blood-perfused canine gracilis muscle in situ, pre-treated with desipramine and phenoxybenzamine
Comparison
Beta 1-selective and non-selective… vs Control experiments
Design
Preclinical
Authors
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Suggests β2-adrenoceptor facilitation of NA release in vivo; leaves open clinical relevance in humans.
Does beta-adrenoceptor blockade reduce nerve stimulation evoked release of endogenous noradrenaline in canine skeletal muscle?
The study provides in vivo evidence that noradrenaline release can be enhanced by activation of prejunctional beta 2-adrenoceptors.
Dahlöf et al. (1987) studied this question.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: