Key result
Beta-adrenergic blockade reduced coronary blood flow and decreased capillary norepinephrine permeability surface product without changing the rate of local release in the canine heart.
In a canine model, beta-blockade reduces myocardial norepinephrine overflow by decreasing transcapillary flux and increasing interstitial uptake, rather than by changing the rate of local release.
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Beta-blockade effects on canine norepinephrine handling warrant caution in patients; leaves open translation to human sympathetic regulation and outcomes.
Cousineau et al. (1984) studied this question. Beta-adrenergic blockade was evaluated on Myocardial norepinephrine overflow and rate of local release. Beta-adrenergic blockade reduced coronary blood flow and decreased capillary norepinephrine permeability surface product without changing the rate of local release in the canine heart.
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