Why the study?
Does norepinephrine elicit peripheral beta 1-adrenergic vasodilation in conscious dogs?
Population
Conscious dogs instrumented for the measurement of cardiac output, arterial pressure, and left ventricular…
Comparison
Norepinephrine administration or endogenous NE… vs Baseline measurements prior to intervention
Design
Preclinical
Authors
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Hypothesis-generating for beta1-mediated norepinephrine vasodilation in dogs; should not yet inform human practice.
Does norepinephrine elicit peripheral beta 1-adrenergic vasodilation in conscious dogs?
In the presence of alpha-adrenergic blockade, norepinephrine elicits potent peripheral vasodilation via a beta 1-adrenergic receptor mechanism in conscious dogs.
Vatner et al. (1985) studied this question.
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