Key result
In a canine model, beta-adrenoceptor agonists caused vasodilatation and modest enhancement of nerve stimulation-evoked vasoconstriction (+20-25%, p<0.01) and noradrenaline overflow (+13%, p<0.05).
Population
Desipramine-pretreated canine blood-perfused gracilis muscle in vivo model
Comparison
Isoprenaline, rimiterol, and ICI 118,551 vs Basal state / control responses
Design
Preclinical
Authors
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Supports modest prejunctional beta2 facilitation in vivo; leaves open clinical relevance versus dominant alpha inhibition.
p-value: p=< 0.01
Prejunctional beta 2-adrenoceptor-mediated facilitation of sympathetic neurotransmission occurs in vivo but is modest compared to alpha-adrenoceptor-mediated inhibition.
Kahan et al. (1987) studied this question. Isoprenaline and rimiterol was evaluated on Vasodilatation, nerve stimulation-evoked vasoconstriction, and noradrenaline overflow (p=< 0.01). In a canine model, beta-adrenoceptor agonists caused vasodilatation and modest enhancement of nerve stimulation-evoked vasoconstriction (+20-25%, p<0.01) and noradrenaline overflow (+13%, p<0.05).
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