Key result
In vivo experiments in rabbits suggest that noradrenaline release may be modulated through facilitatory presynaptic β2-adrenoceptors on sympathetic nerve endings.
In vivo noradrenaline release in rabbits is modulated by facilitatory presynaptic β2-adrenoceptors, which may serve as physiological sites of action for adrenaline.
No takes yet. Share an insight, caveat, or question.
Does not support clinical targeting of presynaptic β2-adrenoceptors; leaves open their role in human sympathetic regulation.
Schmidt et al. (1984) studied this question. Isoprenaline bitartrate vs. Hydralazine was evaluated on Rate of noradrenaline release into the circulation. In vivo experiments in rabbits suggest that noradrenaline release may be modulated through facilitatory presynaptic β2-adrenoceptors on sympathetic nerve endings.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: