Why the study?
Do alpha 2-adrenoceptors modulate the release of norepinephrine from vascular sympathetic nerve endings in humans?
Population
32 healthy volunteers
Comparison
Intra-arterial infusion of drugs acting at… vs Sodium nitroprusside (NIP) or other drug infusions
Design
Other
Authors
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Supports α2-adrenoceptor modulation of NE release in human vessels; leaves open clinical relevance in cardiovascular disease.
Do alpha 2-adrenoceptors modulate the release of norepinephrine from vascular sympathetic nerve endings in humans?
Alpha 2-adrenoceptors modulate the release of norepinephrine from vascular sympathetic nerve endings in humans, and their function remains unchanged during acute changes in junctional NE concentrations.
Grossman et al. (1991) studied this question.