April 1, 1992Journal of Cardiovascular Pharmacology
Nonadrenergic Sympathetic Vascular Control of the Human Forearm in Hypertension
Why the study?
Does local alpha-adrenergic blockade with phenoxybenzamine alter forearm blood flow and neuropeptide Y release during sympathetic nerve activation in hypertensive men?
Population
10 hypertensive men
Comparison
Lower body negative pressure after local… vs Lower body negative pressure before…
Design
Other
Authors
Discussion
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Member takes
Implication
May indicate persistent non-adrenergic vasoconstriction during sympathetic activation in hypertension; leaves open NPY modulation as therapeutic target.
Structured PICO
Does local alpha-adrenergic blockade with phenoxybenzamine alter forearm blood flow and neuropeptide Y release during sympathetic nerve activation in hypertensive men?
P
Population
10 hypertensive men
I
Intervention
Lower body negative pressure (LBNP; -10 mm Hg, 10 min) after local alpha-adrenergic blockade by phenoxybenzamine (60 micrograms x 100 ml-1 x min-1 for 60 min) with continuous propranolol (10 micrograms x 100 ml-1 x min-1)
C
Comparator
Lower body negative pressure before phenoxybenzamine administration
O
Outcome
Forearm blood flow (venous occlusion plethysmography) and regional overflows of norepinephrine (NE) and NPY-like immunoreactivity (NPY-LI)surrogate
In hypertensive men, sympathetic nerve activation induces nonadrenergic vasoconstriction and release of neuropeptide Y, which appears to be modulated by prejunctional alpha-adrenoceptors.
Cite This Study
Kahan et al. (1992) studied this question.