Functional sympatholysis of neuropeptide Y‐mediated vasoconstriction in humans
Key result
Dynamic handgrip exercise blunts NPY-mediated vasoconstriction ~66% compared with sodium nitroprusside.
- P=0.029
- n=12
Why the study?
Neuropeptide Y is released from sympathetic nerves during exercise, but whether neuropeptide Y-mediated vasoconstriction is sensitive to metabolic inhibition in humans was unknown.
Population
12 healthy adults
Comparison
PE vs NPY infusions during SNP control vs dynamic handgrip exercise
Design
Physiological crossover study
Authors
Discussion
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Member takes
Implication
NPY vasoconstriction undergoes functional sympatholysis during exercise in humans; leaves open its role in exercise hyperemia or CV disease.
PICO
P
Population
12 healthy adults (mean age 30 years) undergoing intra-arterial infusions and handgrip exercise to assess functional sympatholysis.
I
Intervention / Comparator
Dynamic rhythmic handgrip exercise vs Sodium nitroprusside (SNP) infusion (15% maximal voluntary contraction)
O
Primary Outcome
Change in forearm vascular conductance (ΔFVC) to NPY infusion, p=0.029
Main Result
Absolute Event Rate: -11% vs -32%
p-value: p=0.029
Cite This Study
Wakeham et al. (2025) studied Healthy adults (n=12). Dynamic rhythmic handgrip exercise vs. Sodium nitroprusside (SNP) infusion was evaluated on Change in forearm vascular conductance (ΔFVC) to NPY infusion (p=0.029). Dynamic rhythmic handgrip exercise significantly blunted NPY-mediated vasoconstriction compared to sodium nitroprusside infusion (ΔFVC -11% vs -32%; P=0.029).