December 1, 2003Journal of Applied Physiology
Exogenous NO administration and α-adrenergic vasoconstriction in human limbs
Why the study?
Does exogenous NO administration blunt alpha-adrenergic vasoconstriction in resting human limbs?
Population
8 healthy males
Comparison
Brachial artery infusion of sodium nitroprusside… vs Brachial artery infusion of adenosine combined…
Design
Other
Authors
Discussion
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Member takes
Implication
Exogenous NO does not blunt resting human forearm vasoconstriction; challenges translation from contracting animal models and leaves open condition-specific effects.
Structured PICO
Does exogenous NO administration blunt alpha-adrenergic vasoconstriction in resting human limbs?
P
Population
8 healthy males
I
Intervention
Brachial artery infusion of sodium nitroprusside (SNP; NO donor) combined with alpha-adrenergic constrictors (tyramine, phenylephrine, clonidine)
C
Comparator
Brachial artery infusion of adenosine combined with the same alpha-adrenergic constrictors
O
Outcome
Forearm blood flow (FBF) and calculated forearm vascular conductancesurrogate
Exogenous NO administration does not blunt alpha-adrenergic vasoconstriction in the resting human forearm, contrary to findings in contracting skeletal muscles of experimental animals.
Cite This Study
Rosenmeier et al. (2003) studied this question.