September 18, 2008Journal of Applied PhysiologyOpen Access

Nitric oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine

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Why the study?

Does nitric oxide inhibit cutaneous vasoconstriction to exogenous norepinephrine via postsynaptic mechanisms?

Population

Human subjects (implied by intradermal microdialysis and background text)

Comparison

Intradermal microdialysis perfusion of NO donor… vs Intradermal microdialysis perfusion of adenosine…

Design

Other

Authors

MSManabu ShibasakiSumitomo Electric Industries (United States)DLDavid A. LowBallarat Health Services SDScott L. DavisBrigham Young University–Hawaii

Discussion

Member takes

Implication

Nitric oxide may attenuate cutaneous norepinephrine responsiveness via postsynaptic mechanisms; leaves open translation to systemic vascular control or therapy.

Structured PICO

Does nitric oxide inhibit cutaneous vasoconstriction to exogenous norepinephrine via postsynaptic mechanisms?

Population

Human subjects (implied by intradermal microdialysis and background text)

Intervention

Intradermal microdialysis perfusion of NO donor sodium nitroprusside followed by increasing concentrations of exogenous norepinephrine (1 x 10(-8) to 1 x 10(-2) M)

Comparator

Intradermal microdialysis perfusion of adenosine followed by increasing concentrations of exogenous norepinephrine

Outcome

Cutaneous vascular conductance (skin blood flow divided by mean arterial blood pressure) and norepinephrine dose required for vasoconstriction onset and 50% maximal responsesurrogate

Nitric oxide attenuates cutaneous vasoconstrictor responsiveness to exogenous norepinephrine via postsynaptic mechanisms.

Cite This Study

Shibasaki et al. (2008) studied this question.

synapsesocial.com/papers/6a8944cd991508d05dc97a4a https://doi.org/10.1152/japplphysiol.91017.2008

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Implication

Nitric oxide may attenuate cutaneous norepinephrine responsiveness via postsynaptic mechanisms; leaves open translation to systemic vascular control or therapy.

Nitric oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Nitric oxide inhibits cutaneous vasoconstriction to exogenous norepinephrine

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider