April 1, 1987Journal of Cardiovascular Pharmacology

Modulation of Noradrenaline Release by Peripheral Presynaptic α2-Adrenoceptors in Humans

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Why the study?

Does intraarterial infusion of alpha-adrenoceptor antagonists modulate noradrenaline release in human volunteers?

Population

15 human volunteers

Comparison

Intraarterial infusions of yohimbine, doxazosin… vs Basal conditions and tyramine alone

Design

Other

Authors

PBP. van BrummelenLeiden University PVP. VermeyLeiden University PTPieter B.M.W.M. TimmermansLeiden University

Discussion

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Implication

Does not support changing alpha-blocker use; confirms presynaptic α2-negative feedback on noradrenaline release in humans.

Structured PICO

Does intraarterial infusion of alpha-adrenoceptor antagonists modulate noradrenaline release in human volunteers?

Population

15 human volunteers

Intervention

Intraarterial infusions of yohimbine (1.0 micrograms/kg/min), doxazosin (0.1 microgram/kg/min), and tyramine (1.25 microgram/kg/min) alone and in combination

Comparator

Basal conditions and tyramine alone

Outcome

Noradrenaline spillover in the forearmsurrogate

The study provides in vivo evidence in humans that presynaptic alpha 2-adrenoceptors modulate noradrenaline release from sympathetic nerve endings via a negative feedback mechanism.

Cite This Study

Brummelen et al. (1987) studied this question.

synapsesocial.com/papers/6a94649dcff80aed1b3ed633 https://doi.org/10.1097/00005344-198704000-00005

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Modulation of Noradrenaline Release by Peripheral Presynaptic α2-Adrenoceptors in Humans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Modulation of Noradrenaline Release by Peripheral Presynaptic α2-Adrenoceptors in Humans

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider