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June 1, 1987Neurosurgery

Phenylpropanolamine: An Over-the-Counter Drug Causing Central Nervous System Vasculitis and Intracerebral Hemorrhage

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Why the study?

Does phenylpropanolamine cause central nervous system vasculitis and intracerebral hemorrhage?

Population

A young woman with intracerebral hematoma and subarachnoid hemorrhage

Design

Case_report

Authors

RGRoberta P. GlickRush UniversityJHJohn HoyingWright-Patterson Air Force BaseLCLeonard J. CerulloNorthwestern University

Discussion

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Implication

Raises possibility of phenylpropanolamine-induced CNS vasculitis with hemorrhage; hypothesis-generating, should not change practice.

Structured PICO

Does phenylpropanolamine cause central nervous system vasculitis and intracerebral hemorrhage?

P
Population
A young woman with intracerebral hematoma and subarachnoid hemorrhage
I
Intervention
Phenylpropanolamine (PPA) in diet pills
O
Outcome
Intracerebral hematoma, subarachnoid hemorrhage, and central nervous system vasculitissafety

Phenylpropanolamine, a common over-the-counter drug, can cause potentially fatal central nervous system vasculitis and intracerebral hemorrhage.

Cite This Study

Glick et al. (1987) studied this question.

synapsesocial.com/papers/6a787cbd6789de8d0af7cebdhttps://doi.org/10.1227/00006123-198706000-00027
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The effect of phenylpropanolamine on ambulatory blood pressure1986 · 31 citations
  2. 2Propranolol antagonism of phenylpropanolamine-induced hypertension1985 · 38 citations
  3. 3A42-12 Drug-induced Pulmonary Arterial Hypertension From Over-the-counter Diet Pills and Methamphetamine Use2026
  4. 4Phenethylamines in pre-workout supplements alter arterial pressure, heart rate, and body temperature in rats2026
  5. 5Myocardial hypertrophy associated with long-term phenylpropanolamine use in a dog2018