Why the study?
Does placebo administration affect specific subperiods of 24-hour ambulatory blood pressure monitoring in essential hypertensive outpatients?
Population
41 essential hypertensive outpatients
Comparison
Placebo administration for 4 weeks vs Baseline measurements and a separate control…
Design
Cohort
Follow-up
4 weeks
Authors
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May confound early office or ambulatory BP changes with placebo effects; leaves open subperiod bias despite 24-h mean resistance.
Does placebo administration affect specific subperiods of 24-hour ambulatory blood pressure monitoring in essential hypertensive outpatients?
While placebo does not affect 24-hour mean ambulatory blood pressure, it significantly lowers blood pressure during the initial 8 hours, likely due to an attenuated alerting response, which could lead to overestimation of early antihypertensive treatment effects.
Mutti et al. (1991) studied this question.
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