Key result
Non-alcoholic fatty pancreas disease in patients with acute coronary syndrome was associated with a significantly higher SYNTAX score compared to those without (12.3 vs 8.2, p < 0.001).
Why the study?
Excess pancreatic fat is linked to cardiovascular disease, but its relationship with coronary artery disease complexity and severity in ACS patients required investigation.
Is the presence of non-alcoholic fatty pancreas disease associated with increased coronary artery disease complexity (SYNTAX score) in patients with acute coronary syndrome?
Observational (n=99)
Is the presence of non-alcoholic fatty pancreas disease associated with increased coronary artery disease complexity (SYNTAX score) in patients with acute coronary syndrome?
Absolute Event Rate: 12.3% vs 8.2%
p-value: p=<0.001
The presence of non-alcoholic fatty pancreas disease detected by ultrasound is associated with higher coronary artery disease complexity in patients with acute coronary syndrome.
Background: Evidence that individuals with excess fat in the pancreas have an increased risk of cardiovascular disease has been growing recently. Risk evaluation in acute coronary syndrome (ACS) patients plays a crucial role for both prognosis prediction and decision-making. Aim: The main aim of this study was to investigate the relationship between non-alcoholic fatty pancreas disease (NAFPD) and the complexity and severity of coronary artery disease as assessed using the SYNTAX score (SXscore) in ACS patients. Methods: A total of 99 consecutive patients with a first-time diagnosis of ACS were recruited. NAFPD was evaluated using transabdominal ultrasonography (TUS). SXscore was calculated using the SXscore algorithm. Results: The patients with NAFPD had a significantly higher SXscore than those without NAFPD (12.3 ± 6.4 and 8.2 ± 4.3, p < 0.001). Univariable analysis showed that hypertension (p = 0.033) and presence of NAFPD (p = 0.001) were associated with increased SXscore. Moreover, multivariable analysis showed that the presence of NAFPD (p = 0.002) was associated with increased SXscore. Conclusions: NAFPD is easily detected by TUS. The presence of NAFPD in ACS patients may be a warning signal of complexity and severity of coronary artery disease.
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Şahin et al. (2022) conducted an observational in Acute Coronary Syndrome (n=99). Non-alcoholic fatty pancreas disease (NAFPD) vs. No NAFPD was evaluated on SYNTAX score (p=<0.001). Non-alcoholic fatty pancreas disease in patients with acute coronary syndrome was associated with a significantly higher SYNTAX score compared to those without (12.3 vs 8.2, p < 0.001).
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