Key result
Electrical stimulation of afferent renal nerves elicits an increase in arterial pressure and heart rate, likely due to widespread sympathetic activation without direct kidney involvement.
Afferent renal nerve stimulation increases blood pressure and heart rate via sympathetic activation, while local renal functions are regulated by other inhibitory reflexes.
Requires caution before clinical translation of renal nerve interventions; extends preclinical evidence on sympathetic activation pathways.
Electrical stimulation of afferent renal nerves elicits an increase in arterial pressure and heart rate. The hypertensive response is presumably due to the widespread activation of the sympathetic nervous system leading to peripheral vasoconstriction. Interestingly, the kidney does not appear involved in this reflex excitatory response to afferent renal nerve stimulation since changes in vascular conductances and excretory functions are equal in both the innervated and denervated kidney, and secondary to changes in renal perfusion pressure. In addition, no changes in renin release from either kidneys are observed during afferent renal nerve stimulation. It is likely that the electrical stimulation of afferent renal nerves activates other reflexes exerting an inhibitory influence on efferent renal nerve activity. Indeed, neural renorenal reflexes which tonically inhibit renal functions have clearly been demonstrated. Furthermore, preferential inhibition of efferent renal nerve activity by cardiopulmonary and sinoaortic receptors has recently been shown during activation of other visceral afferents.
No takes yet. Share an insight, caveat, or question.
Stella et al. (1987) reported a review. Electrical stimulation of afferent renal nerves was evaluated on Arterial pressure and heart rate. Electrical stimulation of afferent renal nerves elicits an increase in arterial pressure and heart rate, likely due to widespread sympathetic activation without direct kidney involvement.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: