Key result
Membrane stretch and fatty acids directly activate large conductance Ca2+-activated K+ channels in rabbit pulmonary artery smooth muscle cells in the absence of cytosolic constituents.
Population
Rabbit pulmonary artery smooth muscle cells (excised inside-out patches)
Design
Preclinical
Authors
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Does not alter clinical practice; leaves open direct BK channel gating by stretch and lipids in human pulmonary vasculature.
Membrane stretch and fatty acids directly activate large conductance Ca2+-activated K+ channels in vascular smooth muscle cells, independent of cytosolic factors or oxygenated metabolites.
Kirber et al. (1992) studied this question. Membrane stretch and fatty acids was evaluated on Activation of large conductance Ca2+-activated K+ channels. Membrane stretch and fatty acids directly activate large conductance Ca2+-activated K+ channels in rabbit pulmonary artery smooth muscle cells in the absence of cytosolic constituents.
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