Key result
A prominent hairpin structure (leader TRS hairpin; LTH) in the 5'-proximal region of the equine arteritis virus genome is a key structural element in discontinuous subgenomic RNA synthesis.
The leader TRS hairpin (LTH) is identified as a critical structural element for subgenomic RNA synthesis in equine arteritis virus and potentially other nidoviruses including coronaviruses.
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Clarifies nidovirus mRNA synthesis mechanism; leaves open antiviral translation.
Born et al. (2004) studied Equine arteritis virus. Mutagenesis of EAV molecular clone was evaluated on RNA structures in the 5'-proximal region involved in subgenomic mRNA synthesis. A prominent hairpin structure (leader TRS hairpin; LTH) in the 5'-proximal region of the equine arteritis virus genome is a key structural element in discontinuous subgenomic RNA synthesis.
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