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We present the case of a 72-year-old female diagnosed with low-grade malignant mesothelioma initially suspected to be a benign left inguinal hernia. The patient presented with progressive left lower extremity swelling and a reducible inguinal mass. Imaging suggested a cystic lesion in the groin, prompting surgical exploration. Pathological findings revealed mesothelioma involving regional lymph nodes. With this case, we aim to highlight an exceedingly rare extra-thoracic presentation and underscore the importance of maintaining a broad differential diagnosis for groin masses. Surgical biopsy and histopathological evaluation remain critical in diagnosing atypical malignancies with unique presentation.
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Hunsberger et al. (2025) studied this question.