Key result
Intravenous injections of several vasoactive amines, including tyramine and amphetamine, released norepinephrine from the heart into the coronary sinus blood of intact anesthetized dogs.
Why the study?
Do intravenous vasoactive amines release norepinephrine from the heart in intact anesthetized dogs?
Do intravenous vasoactive amines release norepinephrine from the heart in intact anesthetized dogs?
Demonstrates that the pharmacologic action of several vasoactive amines is mediated by the release of norepinephrine from the heart.
Supports mechanistic research on cardiac NE release; leaves open human translation.
Intravenous injections of tyramine, phenylethylamine, tryptamine, p-hydroxyamphetamine, amphetamine, ephedrine, mephentermine, and guanethidine were shown to release NE from the heart into the coronary sinus blood of the intact anesthetized dog, while serotonin, methoxamine, and phenylephrine had no such effect. A small but consistent reduction in NE content of atrial appendage was observed following one hour's infusion of tyramine. These observations furnish proof for the concept that release of NE is involved in the pharmacologic action of many of the vasoactive amines.
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Chidsey et al. (1962) studied this question. Vasoactive amines (tyramine, phenylethylamine, tryptamine, p-hydroxyamphetamine, amphetamine, ephedrine, mephentermine, and guanethidine) vs. Serotonin, methoxamine, and phenylephrine was evaluated on Release of norepinephrine (NE) from the heart into the coronary sinus blood. Intravenous injections of several vasoactive amines, including tyramine and amphetamine, released norepinephrine from the heart into the coronary sinus blood of intact anesthetized dogs.
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