Key result
Global longitudinal strain (HR 1.88) and mechanical dyssynchrony (HR 1.48) independently predicted long-term all-cause mortality or heart transplantation in patients with systolic heart failure.
Why the study?
Does the combined assessment of global longitudinal strain and mechanical dyssynchrony improve the prediction of long-term outcomes compared to traditional parameters in patients with systolic heart failure?
Population
240 patients with systolic heart failure (SHF) and LVEF ≤40%
Comparison
Assessment of global longitudinal strain and… vs Standard clinical variables, LVEF, and QRS…
Design
Cohort
Follow-up
median 45 months
Authors
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GLS and dyssynchrony may refine SHF prognosis; leaves open incremental value over LVEF/QRS in prospective studies.
Observational (n=240)
No
Does the combined assessment of global longitudinal strain and mechanical dyssynchrony improve the prediction of long-term outcomes compared to traditional parameters in patients with systolic heart failure?
Hazard Ratio: 1.88 (95% CI 1.07–2.15)
p-value: p=0.03
Combined assessment of global longitudinal strain and mechanical dyssynchrony provides independent and incremental prognostic value beyond traditional LVEF and QRS duration in patients with systolic heart failure.
Chan et al. (2015) conducted an observational in Systolic Heart Failure (n=240). Global longitudinal strain (GLS) and mechanical dyssynchrony (SDε) vs. LVEF and QRS duration was evaluated on All-cause mortality or heart transplantation (HR 1.88, 95% CI 1.07-2.15, p=0.03). Global longitudinal strain (HR 1.88) and mechanical dyssynchrony (HR 1.48) independently predicted long-term all-cause mortality or heart transplantation in patients with systolic heart failure.
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