Key result
The number of metabolic syndrome traits in CAPD patients was positively associated with carotid-femoral pulse wave velocity (r = 0.301, p < 0.01).
Why the study?
Are metabolic syndrome components associated with increased pulse wave velocity in continuous ambulatory peritoneal dialysis patients?
Cross-Sectional (n=148)
Are metabolic syndrome components associated with increased pulse wave velocity in continuous ambulatory peritoneal dialysis patients?
Effect estimate: r = 0.301
p-value: p=< 0.01
Metabolic syndrome traits are independently associated with increased arterial stiffness (measured by pulse wave velocity) in continuous ambulatory peritoneal dialysis patients.
MetS components were associated with higher PWV in CAPD; hypothesis-generating for vascular risk in dialysis, prospective studies needed.
BACKGROUND: Overall, the proportion of deaths due to cardiovascular disease (CVD) reached 40-50% in dialysis patients. Pulse wave velocity (PWV) reflects arterial stiffness and may provide an integrated index of vascular status and CVD risk. Individual components of the metabolic syndrome (MetS) are well-established cardiovascular risk factors. Thus we conducted a cross-sectional study in continuous ambulatory peritoneal dialysis (CAPD) patients to explore the association of MetS components with PWV. METHODS: Prevalent CAPD patients (n = 148, 63 M/85 F) were categorized according to the number of traits of the MetS into one of three groups (No MetS, Risk of MetS, MetS). Due to the effect of peritoneal dialysis (PD), waist circumference was not assessed. Aortic stiffness was assessed by carotid-femoral PWV (C-F PWV). RESULTS: Patients' MetS trait numbers were positively associated with C-F PWV (r = 0.301, p < 0.01), pulse pressure (r = 0.256, p < 0.01), systolic blood pressure (r = 0.233, p < 0.01), and serum albumin (r = 0.205, p < 0.05). In a multivariate regression analysis, PWV was independently determined by age (p < 0.01) and MetS score (p = 0.01). Adjusted R(2) of the model was 0.24. CONCLUSION: MetS traits were closely associated with an increased C-F PWV, even after adjustment for confounders. This suggests that commonly recognized MetS criteria are useful also when predicting CVD in CAPD patients.
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Zhe et al. (2008) conducted a cross-sectional in continuous ambulatory peritoneal dialysis (CAPD) (n=148). Metabolic syndrome (MetS) components vs. Fewer or no MetS traits was evaluated on carotid-femoral pulse wave velocity (C-F PWV) (r = 0.301, p=< 0.01). The number of metabolic syndrome traits in CAPD patients was positively associated with carotid-femoral pulse wave velocity (r = 0.301, p < 0.01).
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