Key result
The addition of choline or methionine to cultured choline-deficient rat hepatocytes increased the secretion of triacylglycerol and phosphatidylcholine by about 3-fold and 2-fold, respectively.
Why the study?
Does the addition of choline or methionine improve VLDL secretion in choline-deficient rat hepatocytes?
Population
Hepatocytes obtained from rats fed a choline-deficient diet for 3 days
Comparison
Cultured in a medium with choline or methionine vs Cultured in a medium without choline or methionine
Design
Preclinical
Authors
Loading...
May restore VLDL secretion in choline-deficient hepatocytes; leaves open relevance to human lipid metabolism.
Does the addition of choline or methionine improve VLDL secretion in choline-deficient rat hepatocytes?
Hepatic secretion of VLDL requires active phosphatidylcholine biosynthesis, which can be compensated by the methylation of phosphatidylethanolamine.
Yao et al. (1988) studied Choline deficiency. Choline or methionine vs. Medium without choline or methionine was evaluated on Secretion of triacylglycerol and phosphatidylcholine. The addition of choline or methionine to cultured choline-deficient rat hepatocytes increased the secretion of triacylglycerol and phosphatidylcholine by about 3-fold and 2-fold, respectively.
Synapse has enriched 3 closely related papers on similar clinical questions. Consider them for comparative context: