Key result
Inhibition of Na+-Ca2+ exchange current by rapid switch to low-Na+ solution or KB-R7943 caused immediate cessation of spontaneous action potentials in guinea-pig sino-atrial node cells.
Population
Guinea-pig sino-atrial node cells
Comparison
Inhibition of Na+-Ca2+ exchange current via… vs Normal spontaneous electrical activity
Design
Preclinical
Authors
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NCX inhibition halts sinoatrial pacemaking in vitro; leaves open its viability as an in vivo therapeutic target.
Na+-Ca2+ exchange current is essential for normal pacemaker activity in guinea-pig sino-atrial node cells.
Sanders et al. (2006) studied this question. Inhibition of Na+-Ca2+ exchange (NCX) current vs. Normal conditions was evaluated on Spontaneous action potentials / pacemaking activity. Inhibition of Na+-Ca2+ exchange current by rapid switch to low-Na+ solution or KB-R7943 caused immediate cessation of spontaneous action potentials in guinea-pig sino-atrial node cells.
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