Aerobic exercise requires urgent examination as a potential intervention to prevent or treat doxorubicin-induced cardiotoxicity in patients with breast cancer.
Does aerobic exercise prevent or treat anthracycline-induced cardiotoxicity in breast cancer patients?
The paper highlights the urgent need for interventions such as aerobic exercise to prevent or treat doxorubicin-induced cardiotoxicity in breast cancer patients.
A nthracycline-containing chemotherapy (eg, doxorubi- cin) is well known to cause dose-dependent, progressive cardiac damage clinically manifest as decreased left ventricular (LV) ejection fraction and, ultimately, heart failure (HF) (Table Unfortunately, the only clinically accepted method to minimize injury is dose modification and/or therapy discontinuation. An important current challenge in breast cancer management is therefore to maximize the benefits of doxorubicin while minimizing cardiac damage. Identification and examination of new interventions to prevent and/or treat doxorubicin-induced cardiotoxicity are urgently required.
Scott et al. (Mon,) conducted a review in Anthracycline-induced cardiotoxicity in breast cancer. Aerobic exercise was evaluated. Aerobic exercise requires urgent examination as a potential intervention to prevent or treat doxorubicin-induced cardiotoxicity in patients with breast cancer.