Key result
Obesity (BMI ≥ 27.5 kg/m2) significantly increased the incidence of stroke and heart disease compared to normal weight (IRR 2.57).
Why the study?
Most studies use standard WHO BMI cut-offs, leaving a limited understanding of the association between Asian-specific BMI categories and stroke or heart disease.
Does obesity increase the incidence of stroke and heart disease in adult Indonesian populations?
Cohort (n=6,688)
Yes
Does obesity increase the incidence of stroke and heart disease in adult Indonesian populations?
Relative Risk: 2.57 (95% CI 1.64–4.04)
p-value: p=<0.001
Obesity, defined by Asian BMI cut-offs, is significantly associated with an increased risk of stroke and heart disease in Indonesian adults, particularly among middle-aged individuals.
May support BMI monitoring in Indonesian adults; extends Asian CVD data yet remains hypothesis-generating.
Background Stroke and heart disease are included in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) concerns. Body Mass Index (BMI) is a modifiable risk factor for stroke and heart disease alike. Most studies classify BMI according to the WHO BMI cut-off point in stroke and heart disease studies. However, there is a limited understanding of the association between the BMI cut-off point in the Asian population category and stroke and heart disease. This study aimed to investigate the incidence rate ratio of stroke and heart disease by BMI categories for Asian population. Methods A 7-year prospective longitudinal study (2007-2014) was conducted on 6,688 adult Indonesian individuals (≥ 35 years) living in 13 different provinces in Indonesia during the survey periods. Data on BMI were collected in 2007. Information on stroke and heart disease was obtained in both 2007 and in 2014. A multivariate-adjusted Poisson regression model was used to estimate the incidence rate ratio (IRR) and 95% confidence intervals (CIs) of either stroke or heart disease or both stroke and heart disease by BMI. Results Out of 6,688 eligible participants, 334 (5%) were judged as stroke and heart disease in 2014. The IRR (95% CI) of stroke and heart disease for participants with obesity was 2.57 (1.64-4.04) compared with those within normal weight. This incidence rate ratio remained among middle-aged adults (<55 years) rather than the older adults (≥55 years); the IRR of stroke and heart disease among obese middle-aged adults was 4.18 (95% CI 2.10–8.31). Conclusions The association was observed between obesity and the risk of stroke and heart disease, especially in middle-aged adults. These findings suggest that lowering BMI through healthy dietary habits and increasing physical activity, especially among middle-aged adults with high education, who are employees, and who live in urban or rural areas may be beneficial for preventing stroke and heart disease.
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Latief et al. (2023) conducted a cohort in Stroke and heart disease (n=6,688). Obesity (BMI ≥ 27.5 kg/m2) vs. Normal weight (BMI 18.5-22.9 kg/m2) was evaluated on Incidence of stroke and heart disease (IRR 2.57, 95% CI 1.64-4.04, p=<0.001). Obesity (BMI ≥ 27.5 kg/m2) significantly increased the incidence of stroke and heart disease compared to normal weight (IRR 2.57).
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