Key result
Higher aortic stiffness predicted cognitive decline, with a significant association observed after excluding one heterogeneous study (β=-0.04; 95% CI -0.07 to -0.01).
Why the study?
Does higher arterial stiffness predict cognitive decline and dementia?
Meta-Analysis (n=3,947)
Does higher arterial stiffness predict cognitive decline and dementia?
Effect estimate: β=-0.03 (95% CI -0.06 to 0.01)
Aortic stiffness is a significant predictor of cognitive decline over an average 5-year follow-up.
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Should not yet alter practice; leaves open whether aortic stiffness is a causal, modifiable target for cognitive decline.
Pase et al. (2011) conducted a meta-analysis in Cognitive decline and dementia (n=3,947). Large artery stiffness (aortic pulse wave velocity) vs. Lower arterial stiffness was evaluated on Decline in Mini-Mental State Examination scores (β=-0.03, 95% CI -0.06 to 0.01). Higher aortic stiffness predicted cognitive decline, with a significant association observed after excluding one heterogeneous study (β=-0.04; 95% CI -0.07 to -0.01).
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