Key result
Voluntary wheel running for 10-14 weeks normalized aortic IKK-NF-κB activation, cytokine expression, macrophage infiltration, and vascular function in old mice.
Why the study?
Does voluntary wheel running reduce arterial inflammation and improve vascular function in old male mice?
Population
Male B6D2F1 mice, including young controls, old cage-restricted mice, and old mice.
Comparison
Voluntary wheel running for 10-14 weeks. vs Cage-restricted (sedentary) controls.
Design
Preclinical
Follow-up
10-14 weeks
Authors
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Hypothesis-generating for late-life exercise in vascular aging; leaves open translation to older adults.
Does voluntary wheel running reduce arterial inflammation and improve vascular function in old male mice?
Short-term voluntary aerobic exercise started late in life reverses age-associated arterial inflammation and vascular dysfunction in a mouse model.
Lesniewski et al. (2011) studied Arterial inflammation and vascular dysfunction with aging (n=26). Voluntary wheel running vs. Cage-restricted controls was evaluated on Aortic IKK-NF-κB activation, cytokine expression, macrophage infiltration, and vascular function. Voluntary wheel running for 10-14 weeks normalized aortic IKK-NF-κB activation, cytokine expression, macrophage infiltration, and vascular function in old mice.
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