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The aim is to determine the duration of oligodendrogenesis and remyelination following spinal cord injury.

January 21, 2015Journal of NeuroscienceOpen Access

Chronic Oligodendrogenesis and Remyelination after Spinal Cord Injury in Mice and Rats

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The aim is to determine the duration of oligodendrogenesis and remyelination following spinal cord injury.
Utilized PDGFRα-reporter mouse lines and GFP-retrovirus-injected rats to assess progenitor fate.
Monitored changes for up to 80 days post-injury.
Analyzed gene expression and cellular activity in chronic spinal cord tissue.
New oligodendrocytes were generated up to 3 months after injury, showing dynamic remyelination activity.
Myelin was observed around axons, indicating effective remyelination, with minimal demyelination at 10 weeks post-injury.
Pro-genitor cell fate genes were actively regulated for at least 4 weeks after injury, highlighting ongoing repair mechanisms.

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Randomized trial uncovers prolonged oligodendrogenesis and remyelination in rodent models, suggesting insight for therapeutic strategies.

Hesp et al. (2015) studied this question.

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