Key result
Statin types and dosages showed no significant differences in blood pressure, except for lower clinic (P=0.007) and daytime (P=0.013) diastolic BP with simvastatin and atorvastatin.
Why the study?
Do different statin types and dosages have varying effects on systolic and diastolic blood pressure in adult patients?
Observational (n=987)
Do different statin types and dosages have varying effects on systolic and diastolic blood pressure in adult patients?
The favorable effects of statins on blood pressure appear to be a class effect, independent of specific statin type or dosage.
Answers are grounded in this paper and cite their sources.
Statin type/dose associations with ambulatory BP are hypothesis-generating; should not yet alter prescribing or guidelines.
We previously demonstrated lower diastolic blood pressure ( BP ) levels under statin therapy in adult individuals who consecutively underwent 24‐hour ambulatory BP monitoring and compared their levels to untreated outpatients. Here we evaluated systolic/diastolic BP levels according to different statin types and dosages. 987 patients (47.5% female, age 66.0 ± 10.1 years, BMI 27.7 ± 4.6 kg/m 2 , clinic BP 146.9 ± 19.4/86.1 ± 12.1 mm Hg, 24‐hour BP 129.2 ± 14.4/74.9 ± 9.2 mm Hg) were stratified into 4 groups: 291 (29.5%) on simvastatin 10‐80 mg/d, 341 (34.5%) on atorvastatin 10‐80 mg/d, 187 (18.9%) on rosuvastatin 5‐40 mg/d, and 168 (17.0%) on other statins. There were no significant BP differences among patients treated by various statin types and dosages, except in lower clinic ( P = .007) and daytime ( P = .013) diastolic BP in patients treated with simvastatin and atorvastatin compared to other statins. Favorable effects of statins on systolic/diastolic BP levels seem to be independent of types or dosages, thus suggesting a potential class effect of these drugs.
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Presta et al. (2018) conducted an observational in Patients on statin therapy (n=987). Different statin types and dosages vs. Other statins was evaluated on Systolic/diastolic BP levels (p=0.007). Statin types and dosages showed no significant differences in blood pressure, except for lower clinic (P=0.007) and daytime (P=0.013) diastolic BP with simvastatin and atorvastatin.
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